Egyptian Red Crescent (ERC) works in harmony with all the components of the International Movement of Red Cross and Red Crescent; the International Federation of Red Cross and Red Crescent (IFRC), the International Committee of the Red Cross (ICRC) and the National RC/RC societies.

ERC enjoys observer status in the Economic and Social Council (ECOSOC) of the United Nations as well as the African ECOSOC.

Strong relationship exists between the ERC and the United Nations Children's Fund (UNICEF), World Health Organization (WHO), Food and Agriculture Organization (FAO), World Food Programme (WFP), the United Nations Population Fund (UNFPA) andUnited Nations Development Programme(UNDP) in various health and food security issues.

It also has strong relationships with the United Nations Office for the Coordination of Humanitarian Affairs (OCHA), the United Nations High Commissioner for Refugees (UNCHR), International Organization for Migration (IOM) and other relevant UN organizations in disaster or migration issues.

ERC also cooperates with several regional and international governmental and non-governmental institutions in the execution of its projects e.g. (U.S. Agency for International Development (USAID), Japan International Cooperation Agency (JICA), The Swedish International Development Cooperation Agency (SIDA), Safe the Children, Caritas, Catholic Relief Services (CRS), etc..

At the national level, activities of ERC are coordinated with governmental authorities at the central or the field level especially in social development, health and disaster management components.